What is a Hisashi Body? Hisashi bodies are eosinophilic, cytoplasmic inclusion bodies found in the cytoplasm of hepatocytes, often associated with viral hepatitis.
They are composed of aggregated intermediate filaments, mainly composed of cytokeratin 18, and are thought to represent a cellular response to hepatocyte injury.
Hisashi bodies are typically 2-10 m in diameter and are round or oval in shape. They are often seen in clusters and can be mistaken for other cytoplasmic inclusions, such as Mallory bodies.
Hisashi bodies are most commonly seen in patients with chronic hepatitis C, but they can also be seen in other types of liver disease, such as chronic hepatitis B, alcoholic liver disease, and non-alcoholic fatty liver disease.
The presence of Hisashi bodies in a liver biopsy is not diagnostic of any specific disease, but it can be a helpful clue in the diagnosis of chronic hepatitis C.
Hisashi Body
Key Aspects
- Eosinophilic, cytoplasmic inclusion bodies
- Found in the cytoplasm of hepatocytes
- Composed of aggregated intermediate filaments
- Associated with viral hepatitis
- Not diagnostic of any specific disease
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Hisashi bodies are associated with a number of different liver diseases, including chronic hepatitis C, chronic hepatitis B, alcoholic liver disease, and non-alcoholic fatty liver disease.
The presence of Hisashi bodies in a liver biopsy can be a helpful clue in the diagnosis of chronic hepatitis C, but it is not diagnostic of any specific disease.
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Hisashi bodies are thought to represent a cellular response to hepatocyte injury.
The presence of Hisashi bodies in a liver biopsy can be a helpful clue in the diagnosis of chronic hepatitis C, but it is not diagnostic of any specific disease.
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Hisashi bodies are a type of cytoplasmic inclusion body that is found in the cytoplasm of hepatocytes.
The presence of Hisashi bodies in a liver biopsy can be a helpful clue in the diagnosis of chronic hepatitis C, but it is not diagnostic of any specific disease.
| Feature | Description |
|---|---|
| Size | 2-10 m in diameter |
| Shape | Round or oval |
| Composition | Aggregated intermediate filaments, mainly composed of cytokeratin 18 |
| Association | Viral hepatitis |
FAQs on Hisashi Bodies
This section provides answers to frequently asked questions about Hisashi bodies, cytoplasmic inclusions found in hepatocytes associated with viral hepatitis.
Question 1: What are Hisashi bodies?
Hisashi bodies are eosinophilic, cytoplasmic inclusion bodies composed of aggregated intermediate filaments, primarily cytokeratin 18. They are typically 2-10 m in diameter and round or oval in shape.
Question 2: What is the significance of Hisashi bodies in liver biopsies?
The presence of Hisashi bodies in liver biopsies can be a helpful clue in the diagnosis of chronic hepatitis C, although they are not diagnostic of any specific disease. Hisashi bodies are associated with hepatocyte injury and can be found in various liver conditions, including chronic hepatitis B, alcoholic liver disease, and non-alcoholic fatty liver disease.
These FAQs provide a concise overview of Hisashi bodies, their characteristics, and their significance in liver biopsies. It's important to consult with healthcare professionals for accurate diagnosis and personalized medical advice.
Conclusion
In summary, Hisashi bodies are cytoplasmic inclusion bodies found in hepatocytes, often associated with viral hepatitis, particularly chronic hepatitis C. Composed of aggregated intermediate filaments, primarily cytokeratin 18, these eosinophilic inclusions provide valuable clues in liver biopsies, although they are not specific to any particular disease.
The presence of Hisashi bodies warrants further investigation into the underlying liver pathology. Their association with hepatocyte injury highlights the need for comprehensive evaluation and management of liver diseases. Ongoing research may shed light on the precise role of Hisashi bodies in liver pathology and contribute to improved diagnostic and therapeutic approaches.
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